Research

Mechanistic studies of skeletal muscle development, regeneration, and stem cell function.

Our research focuses on understanding how genetic and molecular mechanisms control cell behavior within developing and regenerating tissues. We are particularly interested in processes that are inherently spatial and dynamic, where cellular context is essential for interpreting function.

Skeletal muscle development

We investigate how skeletal muscle is built during embryogenesis, focusing on how progenitor cells make fate decisions and organize into functional tissue. By combining genetic perturbations with high-resolution imaging, we identify molecular mechanisms that guide lineage progression and tissue patterning.

Skeletal muscle regeneration

Skeletal muscle regeneration relies on adult muscle stem cells that must balance activation, self-renewal, and differentiation. We study how molecular pathways regulate these decisions following injury, and how tissue architecture influences regenerative outcomes.

Stem cell and synthetic biology

Building on our understanding of muscle stem cell biology, we explore strategies to impart engineered functions to these cells. By integrating synthetic biology approaches with in vivo models, we aim to develop next-generation tools and concepts for enhancing muscle repair.